Diindolylmethane, or DIM, is a metabolite that’s found in cruciferous vegetables like broccoli and kale. This article will go over everything there is to know about DIM and the best supplements available.
This article has been medically reviewed by Dr. Charles Penick, MD
- What is DIM?
- Foods Containing DIM
- Benefits of DIM
- Side Effects of DIM
- How to Take DIM
- Best DIM Supplement
- Final Thoughts
What is DIM?
Diindolylmethane (DIM) is a substance created by the body when the compound indole-3-carbino is consumed. Found in many cruciferous vegetables, DIM is a natural substance believed to have many health benefits.
DIM has gained in popularity because it shows promise as a treatment for various ailments. For example, it is believed to help alleviate hormonal imbalances in women, premenstrual syndrome (PMS), and some cancers. In addition, men may find it useful because it can help with enlarged prostate and lowering prostate-specific antigen (PSA) levels. Other potential uses include treatments for acne, obesity and weight loss.
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- Bok Choy
Benefits of DIM
DIM has been used to treat a variety of health issues. Here are some of the most popular uses of DIM:
Preliminary studies indicate DIM might help prevent the growth of cancer cells. A study on women taking tamoxifen, a drug used to treat breast cancer and DIM supplements indicate daily consumption of DIM “ promoted favorable changes in estrogen metabolism and circulating levels of sex hormone-binding globulin.” 
Regulating Weight Loss
Studies indicate DIM might be an effective tool for weight loss: The administration of 50 mg of DIM “significantly suppressed HFD-induced obesity, associated with a decrease in adipose tissue.” Researchers concluded cruciferous vegetables that can produce DIM “have the potential to prevent or treat chronic obesity.”
Menopause is the natural aging process in women where ovaries stop producing reproductive hormones and menstrual periods permanently stop. Estrogen levels tend to fall during menopause and could break down into “good” or “bad” metabolites. DIM can help produce good metabolites, ease menopausal symptoms, reduce the risk of breast tenderness, decrease cervical problems, and reduce the risk of some cancers.
Prostate Cancer Prevention
Prostate cancer is cancer of the prostate gland and one of the most common cancers in American men. Epidemiological and dietary studies have revealed an association between high dietary intake of cruciferous vegetables and decreased prostate cancer risk.
Elevated levels of androgens (hormones like testosterone) are associated with acne. An imbalance of these hormones could lead to increased sebum production, which is the oily secretion of the sebaceous glands. These secretions lead to clogged pores and cause breakouts. DIM could help keep these hormones balanced, potentially decreasing the risk of acne.
Side Effects of DIM
Studies on DIM have not found any long-term side effects to using DIM supplements. DIM is considered safe for most people when taken by mouth for medicinal purposes. Minor side effects from DIM supplements could include darkening urine, increased bowel movements, nausea, and headaches.
How to Take DIM
Because there are few long-term studies available, consulting with a doctor before taking DIM supplements is advised. Dosage requirements can depend on age, overall health, and other factors. In addition, DIM supplements should be taken with food. It’s also important to stay hydrated when taking DIM supplements.
Best DIM Supplement
There are several DIM supplements to choose from, and the specific supplement a person chooses will depend on their particular needs. Here are a few of the top DIM supplements and their specific benefits:
Each CytoDim™ soft gel contains 100 mg of diindolylmethane (DIM), and is specifically designed to help support healthy estrogen metabolism. On average, the absorption of DIM supplements by the body is minimal due to its crystalline structure. To increase its absorption, CytoDim™ is manufactured using the proprietary True Cellular Formulas Evail™ process: a proprietary blend of MCT oils, non-soy derived lecithin and vitamin E. This product is available in quantities of 60 gels or120 gels.
Systemic Formulas: #843 - Femicrine - Female Endocrine Support contains a powerful blend of herbalomics and phytonutrients that support endocrine health during the natural stages of menopause. This product also helps promote healthy estrogen activity, feminine microbiome, breast health, and healthy estrogen activity.
TruBalance Fem+ contains DIM and other key nutrients:
- Resveratrol and EGCg for maximum antioxidant protection
- B-vitamins and folate for proper cell differentiation
- Calcium-D-glucarate for the proper elimination of excess estrogens
- Magnesium and calcium to help support bone and hormone health
DIM is a compound found in cruciferous vegetables like broccoli, kale, and turnips. Preliminary studies indicate DIM has many health benefits and is helpful for both men and women. Therefore, individuals dealing with any of the above-mentioned ailments should consider using DIM with their doctor’s approval.
Medical Disclaimer: This article is based upon the opinions of Revelation Health. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Revelation Health and associates. This article has been medically reviewed by Dr. Charles Penick, MD for accuracy of the information provided, but Revelation Health encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.
 Cynthia A Thomson 1 2, H H Sherry Chow 3, Betsy C Wertheim, (et al). A Randomized, Placebo-Controlled Trial Of Diindolylmethane For Breast Cancer Biomarker Modulation In Patients Taking Tamoxifen. 2017 Aug;165(1):97-107. doi: 10.1007/s10549-017-4292-7. Epub 2017 May 30. [PMID: 28560655].https://pubmed.ncbi.nlm.nih.gov/28560655/
 Hee Yang 1, Sang Gwon Seo 1, Seung Ho Shin, (et al). 3,3'-Diindolylmethane Suppresses High-Fat Diet-Induced Obesity Through Inhibiting Adipogenesis Of Pre-Adipocytes By Targeting USP2 Activity 2017 Oct;61(10). doi: 10.1002/mnfr.201700119. Epub 2017 Jul 18. [PMID: 28586165]. https://pubmed.ncbi.nlm.nih.gov/28586165/
Indole-3-Carbinol And Prostate Cancer. 2004 Dec;134(12 Suppl):3493S-3498S. doi: 10.1093/jn/134.12.3493S. PMID: 15570059. https://pubmed.ncbi.nlm.nih.gov/15570059/